Take Google Reader, integrate it with the Adobe AIR platform, and enjoy the result of the happy union--a tidy newsreader that lives on your desktop and shares nearly all the attributes of Google Reader with a cleaner interface written to mirror Mac OS X. Users can access all feeds from their account or just favorites and shared stories; search by keyword; and add or remove feeds and tags. About the only thing ReadAir doesn't carry over so far from the online reader is Google's trend analysis, though there are folks who won't mind the omission one bit. Note that the app is in early alpha and will change often, making it a good idea for users to enable autoupdates.
ReadAir is an OSX Themed Desktop Client for Mac or Windows built with Adobe Air. It features a Mac themed scrollbars and form elements, full synchronization with Google Reader Account, add/Remove/Manage tags, subscribe/Unsubscribe from feeds, searching through feeds, and more.