Threat Killer for Windows

Threat Killer is a fully-scriptable malware remover able to remove persistent files, kernel drivers installed by rootkits, registry keys and values, terminate processes (even if critical), delete an entire folder (also using recursive) and much more by executing custom scripts.

The scripts are executed in runtime and you should be able to remove a specific malware without the need to reboot the computer, however is possible that to remove nasty malware is needed to reboot the computer.