With UnlockMe, you can easily determine what's locking your file so you can try and close it. If you can't close it, UnlockMe will automatically unlock it for you, or allow you to terminate the offending process (very useful for getting rid of virus infections).
Probably works; seems tempermental and awkward to use
Jon Westcot
Pros
Instaled without a hitch (following the problems with the previous version not working on XP).
Cons
Seems to only work with one file at a time, not multiple files or a particular folder (or folders). Could not identify files that reported as being used in other software.
Summary
Give it a try; it's free, and it may work for you.