SlickMemo is the best note taking application around. It is also an advanced personal information manager (PIM). It has a tabbed interface, stores all notes in HTML, and can create a reminder for any note. In addition, it has built in backup software. Furthermore, SlickMemo can copy and store files in any note, or create a link to any file within a note.
What's new in this version:
Version 2.0.1 now incudes a handy notes list on the left hand side. It is also fully compatible with USB Flash Keys and able to run on any computer where the key is plugged into.