BackBlaze for Mac is designed to back up every file on your computer actively while you work. With a fairly streamlined setup process, straightforward lists of options, and a decent free account size, BackBlaze works as a solid alternative to backup cloud solutions, though it does lack some of the flexibility you'll find in those other services.
After installing BackBlaze, it will run a quick scan of your computer. The speed will depend on the size of your hard drive and how full it is. We tested this on a 500GB MacBook Pro drive with about 240GB of data stored on it and it took 15 minutes to scan, so the process is relatively fast. The first backup, however, is much slower, as you'd expect. While the app doesn't give you an ETA on the upload, you can expect between 24-48 hours of uploading depending on the number of files and your connection speed, so it will take a few days for the first backup. After that, it will only back up new files or changed files at intervals you can set. Running from your taskbar, BackBlaze is out of the way and doesn't seem to bog down the system much, if at all. The interface is almost a non-issue here as the tool only backs up your data and there is no cloud access like you'd get from a Dropbox or box.net account.
If you need a straight backup tool that costs less than a cloud storage method, BackBlaze is a good option. It costs as little as $4/month for unlimited backup and it runs smoothly on most newer Mac computers. If you're not sure, though, you get 15 days to test the service, which is more than adequate to see if this is the right backup tool for you.