From Mount Sinai School of Medicine Ma'ayan: GATE (Grid Analysis of Time-Series Expression) is an integrated computational software platform for the analysis and visualization of high-dimensional bio-molecular time-series. GATE uses a correlation-based clustering algorithm to arrange molecular time-series on a two-dimensional hexagonal array and dynamically colors individual hexagons according to the expression level of the molecular component to which they are assigned, to create animated movies of systems-level molecular regulatory dynamics. In order to infer potential regulatory control mechanisms from patterns of correlation, GATE also allows interactive interrogation of movies against a wide variety of prior knowledge datasets. GATE movies can be paused and are interactive, allowing users to reconstruct networks and perform functional enrichment analyses. Movies created with GATE can be saved in Flash format and inserted directly into PDF manuscript files as interactive figures.
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