DenoiseMyImage allows you to remove digital noise from your photos while preserving edges. Noise can be caused by low light conditions, high ISO, and small (and dense) camera chip. You don't need a noise profile, just your eyes to get perfect results. The control of the application is straight forward, simple and intuitive. Freeware includes one core support, GPU acceleration, and batch denoising is not available.
Slow, but the paid version is much faster and is only 10 Euros.
Summary
This software does an incredible job of eliminating noise (grain) without destroying much detail. There is some trade-off here, but not nearly to the extent of other noise reduction software. Their website mentioned a watermark on images from the free version, but I could see none, so the freeware version seems to produce an identical image to the paid version. However for only 10 Euros, the gain in speed is probably worth it. I did not see this offered as a Photoshop plugin, which would make it even better.