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Editors’ Review

Download.com staff

ChemSketch Freeware is a powerful yet intuitive chemical modeling tool developed by Advanced Chemistry Development. This free reference software provides professionals, students, and enthusiasts with impressive 2D and 3D visualization capabilities for constructing, viewing, and analyzing detailed chemical structures. It offers access to functions previously reserved for high-end, proprietary suites.

Similar to ChemDraw or Marvin in functionality, ChemSketch integrates both sketching and 3D visualization within a single application. While those programs often require licensing, this freeware version offers a robust set of core features at no cost. The tool prioritizes a user-friendly experience while maintaining depth.

Precision meets accessibility

The program’s interface is expertly laid out, offering an accessible design that will feel familiar to users of CAD tools or digital art software. The 2D sketch page is highly intuitive, providing a well-equipped sidebar containing common elements and bonds, which allows users to build complex structures through simple selection and drag-and-drop operations. The toolbars are also customizable and packed with symbols and templates for a streamlined user experience.

ChemSketch Freeware simplifies the visualization of complex molecular properties with advanced tools that allow users to generate IUPAC names, add stereo descriptors, and display features like Aromaticity with just a few clicks. A key feature is the versatile 3D viewer, which instantly converts 2D models into interactive 3D images. Users can zoom, rotate, and customize these models to gain a deeper, dynamic understanding of molecular geometry and properties.

For advanced users, the inclusion of ChemBasic, a dedicated chemistry-oriented programming feature, allows for the scripting and automation of repetitive tasks. While the program provides comprehensive documentation and is generally user-friendly compared to traditional modeling software, users have noted that the 3D rendering engine, though functional, is not as visually polished or fast. This performance difference is a noticeable drawback during complex structural analysis.

Enlarged image for ChemSketch Freeware
ChemSketch Freeware 0/5
  • Pros

    • Highly accessible
    • Seamless 2D to 3D structure visualization
    • Generates IUPAC names automatically
    • Includes a programming feature
  • Cons

    • 3D rendering can be slow

Bottom Line

Powerful modeling

To summarize, ChemSketch Freeware stands out as an indispensable tool for anyone in the chemical sciences, successfully blending high-level structural analysis with surprising accessibility. Its robust set of features — including the seamless 2D/3D transition, integrated database access, and powerful scripting capabilities — empowers users to visualize and understand complex chemical concepts right from their computer, whether for casual exploration or rigorous scientific research.

What’s new in version 2025

  • Improved π-complex search
  • Expanded ACD/Dictionary
  • Stereoconfiguration in SMILES and InChI
  • Reinstated CAS SciFindern Search 
  • Enhanced copy/paste


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Full Specifications

GENERAL
Release
Latest update
Version
2025
OPERATING SYSTEMS
Platform
Windows
Operating System
  • Windows XP
  • Windows 8
  • Windows 10
  • Windows 7
POPULARITY
Total Downloads
418,100
Downloads Last Week
29

Report Software

Program available in other languages


Last Updated


User Reviews

4.2/5

18 User Votes


Developer’s Description

Generate chemical structure drawing with multiple features.
The latest version lets users quickly and easily draw all kinds of chemical structures including polymers, organometallics, and Markush structures, optimize spatial configuration, and view structures in 2D or 3D. Generate IUPAC and CAS Index nomenclature for molecules with fewer than 50 atoms and 3 ring structures, and get predictions of the octanol-water partition coefficient, logP, along with other molecular descriptors. Access to ACD/I-Lab, our pay-per-use online engine for the prediction of physicochemical, ADME, and toxicity properties, NMR spectra and chemical shifts, and chemical names, is also provided.

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