AlphaTwist is played on a grid of 25 squares with a bag containing 98 letters. Letters are removed from the bag one by one and placed at the top of any column. The player can then claim any words across or down that pass through the letter she just played. When a word has been removed from the board, the remaining letters fall down to fill the space. The game ends when the player fills the grid or does not complete a level within the time limit.