Hands Off! for Mac

From Em Software:

Hands Off! allows you to keep an eye on Internet connections from all applications as to expose the hidden connections, preventing them from sending data without your consent, hence avoiding information leakage. Manage disk access so dubious programs cannot obtain confidential information. Avert permanent changes or data loss by prohibiting disk writing. Prevent viruses and other malware infiltration. Specify which applications should be trusted with specific operations. The flexible configuration enables the smooth running of your activities while maintaining top security.