Geneforge 5: Overthrow for Windows

From Spiderweb Software:

The Shapers have the ability to create life in any form they choose. They can make living tools that obey their commands, plants that can flourish in the harshest wasteland, and powerful monsters that can crush all who oppose them. The Shapers ruled the known lands, and any who tried to rebel or learn their magical secrets were destroyed. But then their creations rebelled. Working with humans jealous of their masters, they stole the secrets of the Shapers and created their own armies. They created and unleashed new, even more powerful creations and matched the Shapers in savagery. And now, years into the rebellion, the war has settled into a gruesome stalemate. The lands are scorched, and city after city falls.