Free to try (30-day trial, limited export, watermark on printouts); $19.95 to buy (Buy it now)
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GS-Calc is a spreadsheet application that will help you to organize your data, track your expenses and incomes, create reports, handle large text files and databases. Its main features include: 12 million rows x 4,096 columns; a unique feature of organizing worksheets in a tree form; efficient memory usage to quickly load and save the largest files; fast pivot tables; optimization and other advanced statistical functions; using up to 16 processor cores during calculations; a unique feature of working in up to 100 synchronized panes to boost your productivity; GS-Calc can be installed on any portable device and used without performing any registry modifications (save the uninstall key); two optional native file formats: Open Document .ods spreadsheet format and exceptionally fast and compact binary format; extensive match/look-up functionality for more precise and fastest possible searching; regular expressions; support for JScripts & VBScripts; organizing scripts hierarchically in trees; 2D/XY and 3D charts capable of handling very large amounts of data; saving workbooks to PDF: saving entire workbooks, single worksheets, ranges or single charts to compact PDF files; a complete set of functions to import, export and convert data in the text, dBase, Clipper, Fox Pro, Excel XML file formats; around 300 built-in formulas including specialized numerical functions: matrix decompositions; linear equation sets with improving iterations; least squares (weighted, constrained), regression with orthogonal polynomials; time series analysis; minimization; linear programming, integer programming and quadratic programming. Both 32- and 64-bit versions are available.
I tried several apps to try and replace Excel and OO Calc (both too bloated) that would run fast on my netbook. While it can't do VBA, the program does just what it needs to, for a small price and an even smaller memory footprint.