Scribe 2.5 is a note-taking program designed by a historian. Think of it as the next step in the evolution of traditional 3x5 note cards. Intuitive and easy enough for a college student, Scribe allows the most meticulous researcher to store extensive notes, digital images, and, in addition to the usual published references, more formatted archival source types than any other bibliographic program. You can create, organize, index, search, link, and cross-reference your note and source cards. You can assemble, print, and export bibliographies, copy formatted references to clipboard (Chicago or MLA style), and import sources from online catalogs (one at a time only). You can store entire articles, add extended comments on each card in a separate field, and find and highlight a particular word within a note or article. Not to mention such features as the outline, timeline, and glossary.
If you know Filemaker, or even if you don't, Scribe is very easy to use. Personally, I use it to store articles I want to refer to later. Using keywords, it's a snap to find what I'm looking for. And, again, at the price, it's a great value.