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From Vargo Anesthesia:
- 68 questions and explanations with review notes made easy from Pharmacology and Physiology in Anesthetic Practice, 4th Edition. Stoelting and Hiller, 2006. Chapters 1-3 - Easy Review for Anesthesia Providers - - Sample Questions - What would cause an increase in a MAC requirement?A) HypothermiaB) Red HairC) Cardiopulmonary BypassD) Female during a menstruationE) A and CAnswer is B, Red Hair (excess pheomelanin production) requires a higher MAC. Causes of increase MAC: Hyperthermia (Not Hypothermia) Red Hair (excess pheomelanin production) Drug induced increases in CNS catecholamine levels Cyclosporine Hypernaremia Pharmacology and Physiology in Anesthetic Practice, 4th Edition. Stoelting and Hiller, 2006. P. 34 One study by the researchers at the University of Louisville, KY showed that red heads require 20% more MAC.(http://health.howstuffworks.com/medicine/surgeries-procedures/redhead-anesthesia.htm)Anti- shivering effect of Meperidine is caused by stimulation of what?A) Mu1 receptorsB) Mu2 receptorsC) Kappa receptorsD) Delta receptorsE) Both Mu1 and Mu2 receptorsAnswer is C, Kappa receptors. Anesthesiology , Naloxone, meperidine, and shivering, 1993 Dec;79(6):1193-201 There are three narcotics below. Which narcotic's clearance is not delayed by the presence of propofol?A) Remifentanil (Ultiva)B) AlfentanilC) SufentanilAnswer is A, Remifentanil. Propofol inhibits the oxidative enzymatic degradation of both alfentanil and sufentanil. (http://painladder.com/tag/sufentanil)