Resistance is set years before Operation Flashpoint's Cold War reached crisis point, and delivers a campaign which forms a prequel to the original game's plot. The game casts the player as Victor Troska, an experienced ex-Special Forces soldier. Having turned his back on his military past, Troska has settled into respectable civilian life on an island just a short distance from the original game's three islands.
However, his situation changes when Soviet forces invade the island group, destroying Troska's idyllic dreams. Reluctant at first to return to a conflict situation, he is forced to participate in, and then lead, the ramshackle Resistance effort, which grows up in response to the Soviet occupation.