KaKs Calculator is a software package that calculates nonsynonymous and synonymous substitution rates through model selection and model averaging. Since existing methods for this estimation adopt their specific mutation models that consider different evolutionary features, leading to diverse estimates, KaKs Calculator implements a set of candidate models in a maximum likelihood framework and adopts the Akaike information criterion to measure fitness between models and data, aiming to include as many features as needed for accurately capturing evolutionary information in protein coding sequences. In addition, several existing methods for calculating Ka and Ks are also incorporated into this software.
What's new in version 2.0
ReleaseSeptember 28, 2010
Date AddedJune 27, 2010
Operating SystemsWindows 2000, Windows Vista, Windows 98, Windows Me, Windows, Windows NT, Windows 7, Windows XP