ExploitShield launched in September 2012 (covered previously by Seth Rosenblatt) with an ambitious goal: to close the yawning security gap for zero-day threats, those nasty exploits that arise upon first notice of a security vulnerability in a browser or other application before developers can fix the hole. Today, the ExploitShield technology gained a lot more visibility as it was acquired by security-software publisher Malwarebytes, whose Malwarebytes Anti-Malware software has been a Top 10 product on Download.com for many years.
As a result of the purchase, Malwarebytes has released a new beta version of the software, now called Malwarebytes Anti-Exploit. It is almost exactly the same program as ExploitShield (with new rebranding from Malwarebytes), so definitely read Seth's original coverage for more information about the "vulnerability-agnostic" software.
One difference I saw in installing the software was that you don't get that "Please close all applications protected by ExploitShield" pop-up warning on install (nor do you need to close your browsers, which is nice). Otherwise, the program seems to run exactly like ExploitShield. We'll likely have to wait until the next official release of Malwarebytes Anti-Exploit (or the flagship Anti-Malware app) in order to see what plans Malwarebytes CEO Marcin Kleczynski has for his new acquisition.