Microsoft Security Essentials
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Full user review
"Avoid if using Thunderbird!"
Has a clean, sensible interface.
My complaint is that it slows down all of Mozilla Thunderbird's functions to a crawl. If you don't use that for your email, I don't know its effect on other software. I had to uninstall MSE to get back my decent email speeds. I never had an alert from MSE so I don't know how effective it is.
May be OK but not for Thunderbird users.