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Full user review
"If GMail is your primary email, get this app"
If you use GMail on the Mac you normally have two basic interfaces, Apple's Mail with all of its well known problems, and the browser, which limits the amount of Mac-ification of the experience.
A single example: clicking a mailto: link in a browser will normally launch Mail. If you use a browser to access your GMail, this is frustrating. If you do use Mail, it's slow.
Mailplane bridges those gaps, providing an application experience over GMail. mailto: links fire up a new message on GMail, spell checking works, you have your Address Book with no effort, etc.
Has problems whenever GMail changes things. And it only works with GMail, so if you have multiple accounts on multiple providers, you may find Mail to be easier to use in the long run.