From Jane, Inc.:
Janetter is a desktop Twitter client for PCs. Janetter offers several themes to choose from 27 standard themes, or create your own custom theme. It supports User Stream and Streaming API: You can read your friends' Tweets in real time. It has multiple twitter account support so that you can use several Twitter accounts at the same time. Multiple time-lines are displayed on one screen, enabling you to search more information in a shorter period of time. It also contains event notifications, customizable wallpaper, Font, and Display Format. You can mute users, words, and applications. The advanced features are keyboard shortcuts, automatic update, pop-up translation, unread management, and support for shortened URLs.
What's new in this version:
Version 4.2.3 improved performance, removed Lockerz picture upload, and fixed some reported bugs.