IObit Malware Fighter
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Full user review
I use it alongside my Anti-virus and oftentimes IObit warns me about programs that are trying to modify my registry, specially when I download and install new programs.
Catches a few spyware and malware too.
Not all real-time protection are on and updates are not automatic but I guess that what you get for using a free version so it's not really a con. I hope IObit makes everything free though like some free anti-viruses & anti-spywares out there. :)
I like keeping IObit Anti-malware in my PC as a back-up for my anti-virus. Oftentimes IObit detects modifications on my registry faster than my anti-virus, which is good. I hope IObit makes a full version for free too.