ClamXav
Full user review
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"Can't use my Mac with ClamAV running"
Pros
Offers the same level of security as the built in virus protection that comes with your Mac OS X.
Cons
Running scans using ClamXav caused my computer to become useless. It's not very robust software yet has leaves a huge footprint on your computer. If you plan to use ClamXav, beware of slowness on your Apple product. I guess this is normal behavior from ClamAV..
Summary
ClamXav is nice because it's "free," but it certainly doesn't run on the computer free of problems. The extra protection, if it offers any, is totally outweighed by how much it slows my Mac down when running scans.