Microsoft Security Essentials
A newer version of Microsoft Security Essentials is available.
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Full user review
"Very clean interface, easy to use"
Low on resources, quick scans(full scans take longer), and free.
None really, though MS has been slow on updating virus lists. Could use some inoculation abilities for frequently targeted system files.
I have MSE running on 6 machines, 3 with win7homepro, 2 with XPhome and one with vista. The smallest amount of ram is 1 gig running xp home, win7 machines have 2, 4 and 8 gigs of memory and vista machine has 2 gig. Never has MSE shown to be a resource hog, the scans it runs are quick though full scans can take a little bit of time if you have a full hard drive. So far none of my machines have come up with any infections. On my sons pc (2gig win7) it has caught a few things, my wifes pc (4 gig win7) it also has blocked a few things.
Are there more feature packed AV's out there? Yes. AVG is a very feature packed free AV. But all of them seem to take up more resources than MSE. Overall I recommend this over all others.