Avira AntiVir Personal - Free Antivirus
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Full user review
"Really 3.5 stars"
It works and (more or less) stays out of your way
Pop up ads encouraging you to go to the paid version. Annoying, and enough to get me to go back to the free version of Avast (which I've never had a problem with; just thought since CNET gave this one a higher rating I'd give it a whirl.
Good stuff - free - what's not to like? Save $80/year over the paid guys.