Wise Registry Cleaner
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Full user review
"Good, not great"
This is one of the better registry cleaners in being reasonably thorough, though I don't think it yet gets at the 64-bit entries in the Vista x64 registry. But it does the 32-bit portion well enough.
Occasionally it will remove an entry that will cause a problem if I remove some of the "unsafe" (amber) ones. It is easy enough to exclude that entry the next time around. I have never had a problem when removing only the "safe" (green) entries.
A good auxiliary cleaner, though I use CCleaner, and more importantly JV16 PowerTools 2009 for additional cleaning. The latter is just now coming out with a true 64-bit version.