RegSeeker offers a powerful registry cleaner, but it's marred by a complex layout and rather slow performance. The program has a plain menu, takes forever to clean your files, and then doesn't really give you any statistics about what it's doing. You have to babysit it to make the most out of it, too. It's still better than cleaning these files manually, but not by much.
When you're installing the program, it tries to hit you with the Delta toolbar. Make sure you deselect all of the boxes, as deselecting only the main box still lets Delta change your homepage and search. RegSeeker's layout is nice to look at, but it's a pain to navigate. Finding the "Clean All" button that everyone will be looking for takes a minute or two. The rest of the navigation panels relate to features that only advanced techies probably need. If you're one of those, you're probably not using this program. Cleaning took about an hour and sent frequent pop-notifications. It would be nice if the program just mentioned those conflicts after it was finished. The program didn't give any sort of analysis once it was done. In fact, it just decided to close itself once it finished cleaning.
If you're a stickler for advanced options, you might find something to like about RegSeeker. Users who just want a faster, less cluttered computer should look for alternatives that are just faster and more efficient than this program.